United States of America

The crew was completing a night training mission out from March AFB, Riverside. While cruising in stormy weather at an altitude of 8,000 feet, the airplane struck tree tops and crashed on the slope of Mt Pallett located 8,4 miles south of Pearblossom. The aircraft impacted the north slope just below the ridge scattering wreckage on both sides of the ridge. All four crew members were killed.
Crew:
Maj Elvin Estes,
Cpt Norman Gassman,
Cpt Raymond Miller,
S/Sgt Roger DuCharime.

The airplane departed Platte Airport for a local pleasance flight with four passengers and a pilot on board. While flying in marginal weather conditions, the airplane was approaching the Robbins Ranch at low height when control was lost. The airplane overturned then crashed in an open field, killing all five occupants. At the time of the accident, weather was slightly worse than forecasted with low ceiling and rain.

While taking off from Charlevoix Airport, the twin engine aircraft encountered difficulties to gain height. It struck an embankment, went through a railway road and crashed in flames. Both pilots were seriously injured and both passengers were killed. More than three weeks later, on October 14, the captain died from his injuries. The aircraft was destroyed by impact forces and a post crash fire.

Shortly after takeoff from Las Vegas-McCarran Airport, while in initial climb, both engines lost power. The pilot informed ATC and requested permission to return for a safe landing but realized it would not be possible. He raised the undercarriage and attempted a belly landing in an open field. The airplane crash landed near the airport and came to rest. The pilot was killed and all five passengers were seriously injured. The aircraft was destroyed.

The crew was involved in a local test flight and the twin engine airplane was used for an electronic test project mission. For such program, a special authorisation was granted to use the aircraft in an overweight configuration. After liftoff, during initial climb, the airplane encountered difficulties to gain height and its speed was too low. It stalled, struck the ground and crashed in flames. All four occupants were slightly injured and the aircraft was destroyed.

On 7 September, 1966, 65-0281 was the first C-141 destroyed. It blew up while simultaneous hazardous maintenance procedures were being performed. Three maintenance members were killed in an explosion of the Right Extended Range tank. The Wing at McChord had recently converted to the StarLifter. The first aircraft had arrived on 9 August 1966. This aircraft, 65-0281, was the third C-141 to be stationed at McChord, and had arrived on base just a week before, on 29 August, 1966. The maintenance teams had minimal practical experience with the new airplane. It was having multiple maintenance difficulties. The Right Extended Range Tank feel gage was erratic, and the AC "Power On" Light was inop. Two electricians were in the cockpit working on the "Power On" Light. A Maintenance Team Chief was also in the cockpit with three trainees. In addition, he was supervising a maintenance team on another aircraft. The Assistant Team Chief had started de-fueling the Right Extended Range Tank to prepare it for troubleshooting. The other fuel tanks were full. Two additional technicians arrived to work on the fuel gage before the de-fueling was complete. One of the electrical technicians connected testing equipment to the fuel tank but failed to ground it. The other technician plugged an extension cord into the external 115V AC receptacle of the APU. The live extension cord apparently came in contact with the case of the test equipment. Electricity flowed through the case, up the cables into the tank. Due to a short in the coaxial shielding a spark was created within the nearly empty tank. The right wing exploded. The Assistant Team Chief standing under the wing, and the technician on the wing were killed almost immediately. One of the technicians in the cockpit was badly burned while exiting the right troop door into a burning pool of JP-4. He died a few days later. The others on the aircraft received only minor injuries.
Source:
http://www.c141heaven.info/dotcom/65/pic_65_0281.php

During the takeoff roll at Alamosa Airport, the pilot raised the landing gear prematurely, causing the aircraft to crash on runway. All six occupants were slightly injured while the aircraft was destroyed by fire.

The crew was completing landing practices onto Lake Michigan. Upon landing off Highland Park, Illinois, the left pontoon struck an unknown floating object, causing a rupture of the fuselage. The airplane came to rest and sank rapidly. Both pilots were quickly rescued.

While in cruising altitude along Annette Island, both engines failed simultaneously. Unable to divert to the nearest airport, the pilot reduced his altitude and ditched the aircraft off the island. The airplane slid for several yards and came to rest. All 11 occupants were quickly rescued while the aircraft was lost.

En route, the seaplane went into an uncontrolled descent and crashed in flames in a glacier located in the region of Juneau. The wreckage was found few hours later in a crevasse and all nine occupants have been killed.