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The airplane departed RAF Swinderby to attack a synthetic rubber plant located in Hüls. Approaching Düsseldorf, it was shot down by the German Flak and crashed in the district of Oberbilk. All four crew members were killed.
Crew:
P/O John Marshall Waddell, pilot,
P/O Walter Edmund Hinchliffe, pilot,
Sgt Ronald William Curtis, wireless operator,
Sgt Neil Rolf Lawson, wireless operator.

The crew departed RAF Spitalgate on a night training exercise. While cruising over the city of Grantham, the airplane collided with a German Air Force Junkers JU.88. Both airplanes dove into the ground and crashed. The Oxford crashed at Dysart Road in Grantham and the JU.88 crashed near Barrowby, west of Grantham. All five crew members in both airplanes were killed.
Crew:
Cpl Samuel John Edwards, pilot,
Sgt Thomas Daye Graham, pilot.

Shortly after takeoff from Duncan Field AFB, the airplane lost height, crashed into a wooden framed building, passed through and struck a private car passing by on the street. The pilot and a second crewmen were killed while 12 other occupants as well as five people on the ground were injured.
Those killed were:
1st Lt Maurice Allen Morgan,
2nd Lt Robert Reichstadt.

The airplane departed RAF Topcliffe at 2056LT on September 2 on an operation to Frankfurt. While returning to base the following night, it crashed in Rectory Lane in Kirton. A house was badly damaged and a 4 year old girl was slightly injured. All five crew members were killed.
Crew:
F/Sgt Donald Machell Bozer, pilot,
F/Sgt Seward Terry Modeland, pilot,
P/O Jackson Corwin Nixon, observer,
F/Sgt Lawrence Milbert Bowen, wireless operator,
Sgt Alexander Frederick Jaggers, wireless operator.

The airplane departed RAF Scampton at 2015LT on August 31 on an operation to Cologne. While returning to base the following night and passing over the Netherlands, it was shot down by a Me.110 and crashed in Asten. The pilot was killed and three other occupants were injured and became PoW.
Crew:
S/L Eric Peter Willcox, pilot, †
Sgt Harry Cecil Gabbitas,
Sgt Jack Lawrence,
F/Lt Douglas Bruce Organ.

The airplane departed RAF Attlebridge at 1739LT on an operation to Rotterdam. Approaching the target area, it was shot down by the German Flak and crashed onto houses located in the district of Schiedam. All three crew members were killed.
Crew:
F/Lt James Okeden Alexander, pilot,
F/Sgt Alexander James Hardy, observer,
F/Sgt John Lionel Briggs, wireless operator.

On the afternoon of Wednesday 27 August 1941 four 256 Squadron Defiants took off from Squires Gate to practice formation flying. Their flight commander (whose name is unrecorded) was recalled back to the aerodrome, and so he handed his flight over to his No. 2, a Sergeant Leonard (RAF). Just after 3.00 p.m. the three Defiants were flying over the sea, a little West of Blackpool Tower, at an altitude of about 2,000 feet and on a North Easterly heading. Some 500 feet below them, flying in a North Westerly direction, was one of 3 SGR's Bothas, L6509. Eyewitnesses on the ground saw the Defiants break formation and, one by one, dive towards the Botha as if making a mock attack and then level out afterwards. Two of the fighters completed the manoeuvre successfully, but as the third Defiant began its dive the Botha suddenly banked to the right and the pilot of the diving fighter, Defiant N1745, JT-P, struck the Botha amidships, cutting it in two and itself losing a wing. The now tail-less Botha stalled and immediately went into a spiral dive, its descent being watched by hundreds-possibly thousands-of shocked civilians and servicemen on Blackpool's seafront. Seconds later it crashed through the roof of the entrance hall of the Central Station, showering aviation fuel over the platforms below, which erupted into a massive conflagration. A huge cloud of thick black smoke quickly rose to a height of several hundred feet over the center of Blackpool. All three occupants of the Botha and both pilots on board the Defiant were killed. At the station, 8 people on the ground were killed while 6 others died the following days.
Botha's crew (3rd SGR):
P/O A. A. Horne, pilot,
P/O K. J. A. Sale, pilot.
Passenger:
Mr. Frank Longson.
Source & photos: http://laituk.org/Botha-Defiant.htm

While on a training exercise, the crew encountered an extremely poor visibility when the airplane collided with a house and crashed at Canons Park, Stanmore. All four crew members were killed.
Crew:
P/O Norma Frederick Thompson, pilot,
Sgt George Horace MacNamara, observer,
P/O Henry John Fuller, wireless operator,
P/O John Maxwell Dobson, air gunner.

Shortly following a night takeoff from Soesterberg AFB, while in initial climb, the airplane went out of control and crashed in Julianalaan in Bilthoven, about two km west of the airbase. All four crew members were killed.
Crew:
Lt G. Lueder, pilot,
Gefr H.-O. Mai, radio operator,
Uffz C. Graf, mechanic,
Obfw C. Leyerer, air gunner.

The airplane departed RAF Wyton in the evening of August 7 on an operation to Essen. Passing over the Netherlands, it was shot down by a Me.110, entered a dive and crashed onto a farm in Overasselt. All seven crew members as well as three occupants in the farm were killed.
Crew:
S/L John Vivian, pilot,
F/O Frank James Needham, pilot,
Sgt George Wilbert Jeffrey, observer,
Sgt John Turner Corbett, wireless operator,
F/Sgt Robert Alexander Ross, wireless operator,
Sgt Kenneth Leslie Rowley, wireless operator,
Sgt Stanley Henry Broyd, air gunner.
Those killed in the farm were:
Mr. Jan Welles,
Mrs. Marie Welles,
Mr. Jan Welles Jr.